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Supporting Research. Empowering Families.

screeningPatients from HDGC families should be followed by physicians, genetic counselors, gastroenterologists, surgeons, pathologists, oncologists, dieticians, and other health professionals. Upper endoscopy with random gastric biopsies (small samples of tissue) is currently the best method to screen for stomach cancer. Unfortunately, diffuse gastric cancer often is not apparent on endoscopy, and biopsies are often negative.

The current screening recommendations are upper endoscopy with biopsies on an annual basis. If possible, biopsies should be reviewed by pathologists who are knowledgeable about hereditary diffuse gastric cancer. Because hereditary diffuse gastric cancer is nearly impossible to detect at an early stage, however, the recommended procedure to prevent stomach cancer is a total gastrectomy, or complete removal of the stomach. Although this procedure is complicated and commonly leads to weight loss, diarrhea, altered eating habits, and vitamin deficiency, it is possibly the only method to prevent stomach cancer in these families.

Screening and Surveillance Resources


New Tool Improves Detection We are excited to share this press release from No Stomach For Cancer Scientific Advisory Council member Raquel Seruca about their latest paper on germline missense mutations. According to Dr. Seruca this paper describes a new tool of analyses to be part of a pipeline that help on the decision of...