Research
For patients and families facing a diagnosis of stomach cancer, dozens of questions emerge. Often we find that our primary care and even specialist physicians have limited time to review all of the current research about gastric cancer. Their focus needs to remain with the patient and the appropriate treatments for each case.
The CDH1 gene mutation was discovered using this DNA sequencing machine at the University of Otago, Dunedin, NZ in 1998. Parry Guilford explains the process to Karen Chelcun Schreiber during her visit to NZ in February 2011.
However, patients and family members often want to search for more information on their own, as some of the founders of NSFC have done.
Maintaining a comprehensive and complete bibliography of gastric cancer research is beyond the scope of NSFC. With the assistance of our Scientific Advisory Council we will occasionally provide information about current studies and access to new discoveries, particularly in the area of Hereditary Diffuse Gastric Cancer, where early identification of one’s risk and potential treatment strategies may be vitally important to a family attempting to manage the health of many individuals who test positive for the genetic cause of this deadly syndrome. Our source for these occasional reports will be our Scientific Advisory Council.
Research Grants
No Stomach For Cancer is proud to be able to award our first research grants.
December 2012
$50,000 to be awarded
Project: Stomach cancer research project to be determined.
December 26, 2012
$10,000 to Centre for Translational Cancer Research, University of Otago, Dunedin, NZ
Project: Genetic Predisposition to Gastric Cancer
Open ended project, with commitment to incremental funding dependent upon progress and developments.
Research Projects & Studies
Supporting research through participation in studies can be both interesting and personally rewarding. Learn more about opportunities to participate that may be of interest to you.
University of Otago, New Zealand | Centre for Translational Cancer Research
Genetic Predisposition to Gastric Cancer (Dec 2012)
Status: Active
Gastric cancer (also known as stomach cancer) sometimes runs in families. This high cancer risk can be due to the inheritance of a faulty gene. We have previously shown that mutations in the CDH1 gene predispose to stomach cancer, however, not all families with a high incidence of this disease have a mutation in that gene. In this project we are aiming to identify additional genes that explain the high incidence of stomach cancer in some families.
Memorial Sloan-Kettering Cancer Center, New York | Memorial Hospital Research Laboratories
Genomic Analysis of Hereditary Diffuse Gastric Cancer Arising in Individuals with
Germline CDH1 Mutation (Dec 2012)
Status: Active
Researchers now have the technology to perform DNA sequencing of a tumor’s entire genome (or genetic material) to determine which gene mutations exist. They can also determine additional changes to the genome including (1) duplications and deletions of portions of chromosomes, (2) alterations outside the DNA that turn genes on and off, and (3) alterations in expression of genes.
We need your help in determining how individuals with germline CDH1 mutation develop potentially lethal stomach cancer. If you or one of your relatives have inherited a germline mutation in the CDH1 gene and had surgery for a visible stomach tumor, you may qualify for participation in this research project.
BC Cancer Agency | Hereditary Cancer Program
Outcomes and Quality of Life after Prophylactic Total Gastrectomy (Sep 2011)
Status: Active
The purpose of this study is to understand the complications and symptoms experienced by individuals who have had prophylactic total gastrectomy and their effects on a person’s quality of life.
Research Updates
Whether supporting research through grants or direct participation in projects and studies, it doesn’t end there. Regular updates on the status of projects that NSFC funds will be provided by those researchers involved in the projects, followed by the final outcome of the projects upon completion. These updates will be published here.
University of Otago, Dunedin NZ
December 2012: Research at the University of Otago, Dunedin NZ
Research Papers
This information is not intended as, nor should it be considered a substitute for, professional medical advice, professional diagnosis, opinion or treatment to you or to any other individual. Ask your physician or other healthcare provider to assist you in interpreting any information on the website or links to other websites, in applying such information to your individual case.
Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research December 2009
Rebecca C Fitzgerald, Richard Hardwick, David Huntsman, et al.
Prophylactic total gastrectomy for hereditary diffuse gastric cancer: surgical and pathological results May 2009
S.S. Yoon, D. Patel, D.C. Chung, G.Y. Lauwers, Department of Surgery, Center for Cancer Risk Analysis, Department of Medicine, Department of Pathology, Massachusetts General Hospital, Boston MA 02115 USA
Endoscopic Surveillance of Patients With Hereditary Diffuse Gastric Cancer November 2012
Hiroshi Fujita MD PhD, Jochen K.M. Lennerz MD PhD, Daniel C. Chung MD, Devanshi Patel MS CGC, Vikram Deshpande MD, Sam S. Yoon MD, and Gregory Y. Lauwers MD.
Pregnancy after prophylactic total gastrectomy January 2010
Pardeep Kaurah, Rebecca Fitzgerald, Sarah Dwerryhouse, David Huntsman.
